Survivin、Fas與FasL在宮頸癌介入化療前后組織中的表達及意義.pdf

1、青島大學(xué)碩士學(xué)位論文Survivin、Fas與FasL在宮頸癌介入化療前后組織中的表達及意義姓名：董艷申請學(xué)位級別：碩士專業(yè)：婦產(chǎn)科學(xué)指導(dǎo)教師：王蓁20120610ExpressionofSurvivin，F(xiàn)asandFasLincervicalcarcinomatissuebeforeandafterthearteriafemoralisinterventionalchemotherapyandclinicalsignificance

2、AbstractObjeetiveToevaluatedifferentexpressionofSurvivin，F(xiàn)asandFasLincervicalcarcinomacellsbeforeandaftertheartefiafemoralisinterventionalchemotherapyandclinicalsignificance，andtoanalyazetheircorrelationbyexamingtheirpos

3、itiveratesinthecervicalcarcinomaandtoinvestigatetherelationsofSurvivin，F(xiàn)asandFasLandthetheprocessofinvasionandmetastasisofcervicalcarcinomascombiningtheclinicopathologicalfeatures(surgicalpathologicalstage，histologicalty

4、peandlymphmetastasis)MethodsSamplesfrom40casesofnormalcervix，30casesofcervicalintraepithelialneoplasia(ClN)and56cervicalcancerwitllstageIBIIB，whichincludedtissuesbeforeandaftertheinterventionalchemotherapysampleswereexam

5、inedandmarkedthroughPV6000immunohistochemicalmethodforSurvivin，F(xiàn)asandFasLWeexaminedtheircorrelationsandrelmions、Ⅳiththeclinicopathologicalstage，histologicalgradeandhistologicaltypeoftheendometrialcarcinomasbyexamingthepo

6、sitiveratesoftheSurvivin，F(xiàn)asandFasLBesides，theirrelationsbetweenthechangeofthemandclinicalefficiencywereasloanalyzedResultsBeforetheintervenlionalchemotherapyThepositiveratesoftheexpressionofSurvivinandFasLwere857％and911

7、％，thepositiveratesofFaswas482％，aftertheinterventionalchemotherapythepositiveratesoftheexpressionofSurvivinandFasLwere285％and464％，thepositiveratesofFaswas964％，theexpressionofSurvivinandFasLdecreasedandthatofFasincreasedsi

8、gnificantly(P005)IncervicalcancerthechangingofFasexpressionWassignificantlynegativecorrelatedwiththechangingofSurvivinexpression(r09580，P005)，whilesignificantlynegitivecorrelatedwiththechangingofFasLexpression(r=09530，P0

9、05)3Afterthearteriafemoralisinterventionalchemotherapythechangeofthethreeapoptosisproteinswasmuchmore，theclinicalefficiencywasmuchbeaenConclusionThechangesofSurvivin，F(xiàn)asandFasLexpressionweresignificantlyrelatedwithcervic