MMP-9、TIMP-1及ETS-1在扁平苔蘚中的表達及意義.pdf

1、 分類號： R75 密級：不保密 UDC：610 學校代碼：11065 碩士學位論文 MMP MMP-9、TIMP TIMP-1 及 ETS ETS-1 在扁平苔蘚中的表達及意義 在扁平苔蘚中的表達及意義 杜杰 指 導 教 師 王桂芝 教授 王君 副教授 學科專業(yè)名稱

2、 皮膚病與性病學 論文答辯日期 2015 年 6 月 6 日 Expression and signification of matrix metalloproteinase -9 and its tissue inhibitor of metalloproteinase - 1 and Ets-1 in lichen planus. Abstract Objective:To investigate the expre

3、ssion and significance of matrix metalloproteinase -9 (matrix metallpproteinase-9,MMP-9) and its tissue inhibitors of metalloproteinases - 1 (tissue inhibifor of metalloproteinase-1,TIMP-1) and Ets-1 (E26 transformation-

4、specific) in lichen planus. Methods:Immunohistochemistry was used to detect the expression of MMP-9﹑TIMP-1 and Ets-1 in 40 cases of LP lesions and 20 cases of normal skin tissues. Results:The expression of MMP-9,TIMP-1

5、and Ets-1 in lichen planus group were higher than those in the healthy control group (p0，P<0.05). Conclusion:MMP-9、IMP-1 and Ets-1 were all over expressed and positively correlated in LP，these may be associated with t