水相中‘一鍋法’Wittig反應(yīng)的研究和手性P，O-配體的合成及其在不對(duì)稱烯丙基烷基化反應(yīng)中的應(yīng)用.pdf

1、浙江大學(xué)碩士學(xué)位論文水相中‘一鍋法’Wittig反應(yīng)的研究和手性P，O配體的合成及其在不對(duì)稱烯丙基烷基化反應(yīng)中的應(yīng)用姓名：岳從永申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：化學(xué)指導(dǎo)教師：吳金龍戴偉民20060101Abslraelnlemos婦consistsof廿1reeparts：the8tudyon“oncpot’Wjttigol鰳nation訊aq辯。駐s擻翻江譙es撼dyo玨syn盎esiS醴∞vel冀0一ligan丞矗ndappl沁旋on攮pd

2、cat破yzedas”砌e锨c砒lylicalkylation；and也ee鞴efimen瓴lsec垃onInthefirstpan，也edetailsofaqueouS“onepot”Wittigole矗n撕onarepmsentedAb娃efov酬ewon強(qiáng)eWi顫gole蠛na土ionisgiven，includi芏lg如ere剃onmcchanism，stereOchemistfyan矗t垂le僦entdgvelo掰I麟t氈mi

3、c∞wave—assistodWlt蛀gOl《inati講lalldaqueousreactiotlsof啦出ili撇da11dsemis詛bilizcdylides晰t量larom撕oaldehydesThediscussionis也enfocusedonollr∞sul括of‘‘one巾ot”Wi砸greaction戧lrriedouti箍砩瑟S婦ply酚殛蘸玨g彝s毛|耋踟sio矗醴懿建d馥弦e，a魏奎&《醴攀la_bromoac

4、etdte，abromoacetoni砸leora如rD忸oacelamide)，andPI氌3inwateroontaillingLiOHand12MLiCl，t11eolefinproductswercobtai聰din70一99％yieldsMoS垂ofthe蠲嘲駐s獺量圭主g羚aetio趕seo鰳pl斟cedwi艇魏5—30f致l毽oxeept始rso琳eunreactive甜dehydes、w璇chrequiredalon藏e

5、rreaction畦mesofl一3hThera60sof露：Zisomersvary、^，imthestrucnwosofmealdehydes，ranging療o(wú)m100：0to55：45王芏lthesecondpan，our硪bndevotedtotlesyn出esisofaxiallyc址rdEOiigands稻rP垂ca鯫lvzedasy臻瞳毪e話e箍王蹬主cal繁yla蘸on逸最ddIress醴An誣由對(duì)畦t酡t主。玨iso

6、uninedonthemechaIlismandclassmca_tionofasymmetricallylicaIl汀lation，asweIlastherecentadvancenlclltinsynthesisofchiralligands，Thedirectedo《壕ofnet舔鑫專主。玨圓oM)v8a藏)l巍鑫芏主eamidosis疆io蠡畦f醅usei蘸譙esv毪氐s主sofⅫc(diǎn)liralRO，ii譬andsScve蹦chj

7、腳P，Oli鐾andsweresyⅡtllesized洫this8tudyw誠(chéng)(heirabs01utstereochemistrydetenninedbyXraycrystalsmlctLlralanalysisThenewlysyn綴e蛙zedc輛f8lliga建dsw程eev翻毽atedfore攫ieie￡瓣yinPd，al掘lyzedasymme啦c站lylica豫yl撕onmtheexpcrimontalsectiOn，tll

8、ede協(xié)iledreactionprocedures，compollllddl瓤acte五zationdata，andrcfcroncesarepresentedTheXraycrysta王姍c1皤al鑫n氌lvsisd戤穗of氌eehiralliga致硅an蓮壕e辯Lechansfofd。ter撒in毹ion西eeof鏹oasylnmctricaJlylica墩ylationprodllctsarcgivcnint11eAppendi